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Total of 541 studies included, 528 of them were extracted from three databases searched (Fig 1 and S1-S3 Tables in S1 File). Of these, 494 studies were excluded through title and abstract screening leaving 47 studies for full-text review. Trianex (Triamcinolone Acetonide Ointment)- FDA total of 42 of them were finally included in this study and 29 of them were included in the meta-analysis.

All included studies were moderate to high in quality (Table 1 and S4 Table in S1 File). The estimated summary reproductive number based on the 29 studies included in the meta-analysis was 2. We found a very high heterogeneity (99. However, we did not find any evidence of publication bias (Fig 3). We used the subgroup analysis to address the heterogeneity of the reported reproductive number video rectal exam selected studies characteristics.

Their results occult blood test reported in Table video rectal exam and the details results are presented in the S1-S5 Figs in S1 File. We found heterogeneity of the reported reproductive number across the countries for which the reproductive number were estimated, video rectal exam and methods that were used to estimate the reproductive number, video rectal exam the total number of cases that was used to estimate the reproductive number, and the type of the video rectal exam numbers video rectal exam were estimated.

For instance, the estimated reproductive number was higher in outside of China (R, 4. However, in the country level, the highest reproductive number was reported for France (R, 6. South Korea was the only country reported 3162 cases (R, 3. Variations were also found across the type of reported reproductive numbers- the time-dependent reproductive number was found around double (R,4.

However, we found, through using the meta-regression, these differences were only significant across the countries of the reported reproductive number and the methods used to estimate the reproductive number. Their findings were in line with our estimated summary reproductive number. Only a study conducted for Diamond Princes Cruise Ship, Japan reported a very high reproductive number, 14. However, this estimated reproductive number was conditioned for not to be applied any preventive intervention and the infected video rectal exam can mix randomly to the non-infected persons.

When preventive interventions applied this number was reduced to 1. A total video rectal exam 42 studies selected for this study of which 29 studies were included in the meta-analysis. Majority of the included studies were conducted in China. We found evidence of higher heterogeneity of the reported reproductive number across different studies. The sources of heterogeneity were the country for which the reproductive number was estimated, models and methods that were used to estimate the reproductive number, and the total number of case that was used to estimate hexoprenaline reproductive number.

The average estimated reproductive number was 2. However, this estimate is lower video rectal exam the previous summarized reproductive number of coronavirus, 3. However, our estimated reproductive number is still very high that could have the potential to an exponential increase in new infections.

Moreover, the estimated number is still very higher than previous Atropine Sulfate (Isopto Atropine Sterile Topical Ophthalmic Solution)- Multum of coronavirus like infectious diseases, such as severe acute respiratory syndrome (SARS) and the Middle East respiratory syndrome (MERS) if we considered the period between the when was estimation done and infections were initially detected.

For instance, the reproductive numbers of SARS video rectal exam MERS were reduced to 0. There are numerous reasons for such a higher reproductive number. Moreover, coronavirus infected patients may not show symptomatic characteristics upto two weeks of infection.

This pre-symptomatic stage is another vital source to increase new infections exponentially as in this period an infected person is usually confounded in the community video rectal exam other people. This study also found evidence of the very high (99. For instance, the reproductive number found higher for the countries where no restriction was applied, video rectal exam restriction was applied in delayed. These implications act to control virus transmission from video rectal exam infected to the susceptible and reduce the new infections.

We found the type of reproductive number considered was another important source of heterogeneity of the estimated video rectal exam number.



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