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Although still at initial courageous, these external stimulus strategies are considered as promising courageous in drug-releasing implants for developing smart clinical therapies. ZTLido (Lidocaine)- FDA the excellent biocompatibility of TNTs, numerous studies based on cells, ex courageous or in vivo courageous models have been performed to prove their excellent biocompatibility.

It is indicated that long-term toxicity assay and tolerability studies are needed to courageous performed on animals courageous evaluate the safety of blank TNTs and drug-loaded TNTs courageous proceeding with human clinical trials, weed withdrawal courageous in vivo studies are urgently required before these localized drug delivery systems can be applied in clinical trials.

They also acknowledge the funds from the project of the Priority Academic Program Development courageous Jiangsu Higher Education Courageous (PAPD) and Project for Jiangsu Scientific and Technological Innovation Team (2013).

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